(76,79) The histopathologic pattern is that of epidermolytic hyperkeratosis (EHK), in which the keratinocytes in the granular and spinous layers display cytoplasmic
vacuolation, reticular degeneration, coarse keratohyalin granules, and perinuclear eosinophilic inclusions (Figure 8, B).
(11) Pulmonary lesions included edema, fibroplasia, infiltrations, hemorrhage, periarteritis, endothelial swelling and
vacuolation, lymphoid hyperplasia, congestion, and thrombosis.
Heart section from BJME-treated rat showing distorted histological framework of the myocardium with evidence of
vacuolation (thick arrows) and necrosis (thin arrows); C.
The classification of the severity of histopathological changes observed were: Stage I: cytoplasmic
vacuolation, inflammatory infiltrate, infiltration of adipocytes; Stage II: congestion and steatosis; Stage III: granuloma.
Histologically,
vacuolation in the white matter of the brain and the spinal cord as well as demyelination and axonal degeneration have been described.
In Case 2, H & E staining displayed
vacuolation and fragmentation of muscle fibers, with orange-colored inclusion bodies in a significant amount of degenerated fibers, and immunohistochemistry staining revealed the absence of membrane protein of sarcoglycan.
There was an increase in interstitial fibrosis; many of the fibers appeared degenerative, some showed extensive
vacuolation, and others were in the process of regenerating.
In study by Parihar et al.30 all the cases showed epidermal thinning and pigment incontinence, and 85% cases showed basal layer
vacuolation.
According to the severity, sinusoidal dilatation, inflammatory cell infiltration, congestion, degeneration, and cytoplasmic
vacuolation were scored as 0 (normal), 1 (mild), 2 (moderate), and 3 (severe).
(a) Shows Endometrial Glands in Secretory Phase, H and E 100x, (b) Shows Endometrial Gland in Secretory Phase Exhibiting Subnuclear
Vacuolation and Stroma showing Decidual Changes, H and E, 400x, (c) Shows Endometrial Glands in Proliferative Phase, H and E, 100x, (d) Shows Endometrial Glands in Disordered Proliferative Phase, H and E, 100x
(2,3) The illness is hypothesized to arise from the production of misfolded prion proteins, ultimately leading to
vacuolation, neuronal loss, and the spongiform appearance characteristic of CJD.
The examinations focused on renal tubules for the presence of dilatation,
vacuolation, apoptosis, and necrosis.
vacuolation - the state of having become filled with vacuoles