Hydropic Degeneration:
Vacuolated swelling of the cytoplasm of renal cells of the NPs-treated rats was seen in the renal tissues of all rats subjected to Ti[O.sub.2] NPs with variable impacts in respect to dose and exposure duration (Fig.
A shave biopsy of one of the lesions was performed that showed a proliferation of nests of basaloid cells on the dermis with palisading and rare
vacuolated clear cell change.
In Lobatus gigas, there are two types of secretory cells: pyramidal (or crypt) cells that are short, cone-shaped, and present in small groups, and
vacuolated cells are taller and have
vacuolated cytoplasm (Gros et al.
(3) The common characteristic of these lesions is the presence of
vacuolated or foamy macrophages.
A mild amount of
vacuolated spaces was also present in the gray matter.
In kidney, extensive haemorrhages, polymorphic nephritic tubules, fibrosis around the inflamed nephritic tubules, constricted nephritic tubules with
vacuolated surrounding, degeneration of nephritic tubular epithelium (Figure 2a), vacuolation in haematopoietic tissue, cellular and nuclear hypertrophy, degeneration of tubular epithelium (Figure 2b), nephritic tubule inflammation, widen lumen and thickening of luminal lining (Figure 2c) and granuloma formation (Figure 2d) were observed.
The round stromal cells mostly had slightly eosinophilic cytoplasm with some showing a more
vacuolated or foamy appearance.
Hematoxylin and eosin (H & E)-stained sections demonstrate numerous
vacuolated areas (arrows) surrounded by a diffuse, mixed inflammatory infiltrate (A; original magnification x20) and numerous epithelioid histiocytes with small, circular yeast cells (arrows), characteristic of H capsulatum (B; original magnification x 40).
The histological sections showed moderate cellularity consisting of irregular clusters and cords of oval to polygonal epithelioid cells embedded in a mucinous and
vacuolated stroma (Figure 2A).
The histopathological features showed presence of mucous cells,
vacuolated cells, spongiosis, micro-abscesses, cholesterol crystals, hemosiderin and inflammatory infiltrate.
Histologically, MNH has nodular or lobulated architecture with two main cell subpopulations: one type consists of polygonal cells with round nuclei and
vacuolated cytoplasm as a result of abundant glycogen, while the second type of cells is characterised by oval nuclei and dark basophilic cytoplasm with infiltrative or invasive growth patterns into the dermis and surrounding tissues.
vacuolated - formed into or containing one or more vacuoles or small membrane-bound cavities within a cell