modifier gene


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Related to modifier gene: recessive epistasis, epistatic
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Noun1.modifier gene - a gene that modifies the effect produced by another genemodifier gene - a gene that modifies the effect produced by another gene
modifier
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
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Junctophilin-1 is a modifier gene of GDAP1-related Charcot-Marie-Tooth disease.
Short Communication - Association of SNP in JPH1 gene with severity of disease in Charcot Marie Tooth 2K patients
The authors found MEFV as a susceptibility and modifier gene in BD.
Coexistence of familial Mediterranean fever and Behcet's disease: a case report
Such modifier gene identification was described for polycystic kidney disease using [kat.sup.2J] (kat: kidney, anemia, and testes phenotype) mutant mice [21] and multiple intestinal neoplasia using min (multiple intestinal neoplasia) mutant mice [22].
Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation
Because each set of iPSCs is specific to the individual from whom they arc derived, researchers can compare the sets to identify molecular differences, such as a modifier gene active in one person but not the other.
Powerful new tool for studying, treating blood diseases
Considering all data, human homologous of Bop gene (BOP) seems to be candidate modifier gene for HCMP in which both cardiac hypertrophy and cardiac contraction have central role.
The variations of BOP gene in hypertrophic cardiomyopathy\Hipertrofik kardiyomiyopatide BOP geni varyasyonlari
A genome-wide scan carried out by Bykhovskaya et al (96) using parametric analysis of the Arab-Israeli family failed to identify a single major nuclear modifier gene. However, they reported a candidate locus for a nuclear modifier gene associated with the mtDNA A1555G mutation in a same family using nonparametric analysis.
Role of connexin 26 (GJB2) & mitochondrial small ribosomal RNA (mt 12S rRNA) genes in sporadic & aminoglycoside-induced non syndromic hearing impairment
Indeed, when evolving populations become fixed for adaptive and ameliorative mutations, distinction between allele replacement and modifier gene occurrences is no longer possible, unless a genetic survey of the population is continuously conducted.
Evolution of resistance in Culex pipiens: allele replacement and changing environment
Because each set of iPSCs is specific to the individual from whom they are derived, researchers can compare the sets to identify molecular differences, such as a modifier gene active in one person but not the other.
Powerful new tool for studying, treating blood diseases
Thus, this modifier gene is of a qualitatively different character than that used in the study of the evolution of recombination, mutation, or migration (Feldman 1972; Feldman et al.
On the evolution of phenotypic plasticity in a spatially heterogeneous environment
The researchers also point out that previous mouse studies have implicated the modifier gene on chromosome 4 in audiogenic seizures, another form of epilepsy.
Mice reveal three epilepsy genes
(1998) reported that one major gene and one modifier gene were responsible for conditioning of reduced palmitic acid content in N87-2122-4.
Molecular mapping genes conditioning reduced palmitic acid content in N87-2122-4 soybean. (Crop Breeding, Genetics & Cytology)
Indeed, the concept of a CF modifier gene is not new (29).
Cystic fibrosis syndrome: a new paradigm for inherited disorders and implications for molecular diagnostics

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