The second study, ERADICATE, which compares ceftobiprole to daptomycin with or without
aztreonam in the treatment of patients with Staphylococcus aureus bacteremia (SAB), is ongoing and topline results are expected in the second half of 2021.2 Both studies are required for an NDA of ceftobiprole in the U.S.
According to details, the drugs that are short in the market include Asparaginase (Injection 10,000IU),
Aztreonam (Injection 500mg and 1gram), Barium Sulphate Aqueous (Suspension).Dactinomycin (Injection 500mcg), Deferoxamine (Injection 500mg), Ephedrine (Injection 30mg/ml), Glycopyrrolate (Injection 0.2mg/ml), Imatinib (Tablets 100mg and 400mg).
The antibiotics used were polymyxin B (PB 300mg), doxycycline (DO 30mg), gentamicin (CN 10mg), amikacin (AK 30mg), imipenem (IMP 10mg), ciprofloxacin (CIP 5mg), meropenem (MEM 10mg), trime thoprim/sulmethoxazole (SXT 25mg), sulzone (SCF), minocycline (MH 30mg), chloramphenicol (C 30mg), vancomycin (VA 30mg), linezolid (LZD 30mg), erythromycin (E 15mg), ceftazidime (CAZ 30mg), and
aztreonam (ATM 30mg).
Susceptibility testing showed that the initial Kp2588 blood isolate was resistant to most cephalosporins and
aztreonam but susceptible to cefepime, carbapenems, amoxicillin/clavulanic acid, piperacillin/tazobactam, amikacin, and tigecycline (Table).
(4) These are zinc-dependent beta-lactam-hydrolyzing enzymes with board spectrum activity, which hydrolyze carbapenems and other beta-lactam antibiotics, except for
aztreonam. (5) The MBLs are not inhibited by beta-lactamase inhibitors but their functions are blocked by zinc chelating agents (EDTA).
Maximum resistance was seen with cefotaxime (63.63%) and
aztreonam (59.09%).All GNB were sensitive to colistin (100%) followed by imipenem (74.07%) and amikacin (72.22%).
The following antibiotics were used for antimicrobial susceptibility testing: ampicillin, amoxicillin-clavulanic acid, cefuroxime, ceftriaxone, ceftazidime, cefotaxime, cefipime, sulfamethoxazole trimethoprim, imipenem, meropenem,
aztreonam, ciprofloxacin, levofloxacin, amikacin, gentamicin, tobramycin, piperacillin-tazobactam, cefoperazone-sulbactam.
The study developed statistical methods to predict phenotypic resistance from resistance genes for various combinations of the four bacterial species and the antibiotics gentamicin, tobramycin, ciprofloxacin, levofloxacin, trimethoprim-sulfamethoxazole, ertapenem, imipenem, cefazolin, cefepime, cefotaxime, ceftazidime, ceftriaxone, ampicillin, piperacillin and
aztreonam. Average positive predictive values for predicting phenotypic resistance were 91% for E.
New Delhi Metallo [beta]-lactamase 1 (NDM-1) is a novel wide range [beta]-lactamase with the capacity to inactivate all [beta]-lactams except
Aztreonam (Drawz et al., 2014).
The antibiogram pattern of isolates showed that Maximum resistance of Acinetobacter spp and Pseudomonas were seen in
Aztreonam, Cefipime, Doripenem, Imipenem, Ciprofloxacin, Piperacillin/ Tazobactum.
(20) The following antimicrobial agents were examined: amikacin (30 [micro]g),
aztreonam (30 [micro]g), cefepime (30 [micro]g), cefotaxime (30 [micro]g), ceftazidime (30 [micro]g), cefuroxime (30 [micro]g), ciprofloxacin (5 [micro]g), colistin (10 [micro]g), gentamicin (10 [micro]g), imipenem (10 [micro]g), meropenem (10 [micro]g), piperacillin (100 [micro]g), piperacillin/tazobactam (110 [micro]g), tobramycin (10 [micro]g), and trimethoprim/sulfamethoxazole (23.75 [micro]g/1.25 [micro]g).
daptomycin (plus optional
aztreonam for Gram-negative infections) in the treatment of SAB.