megaloblast

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meg·a·lo·blast

(mĕg′ə-lō-blăst′)

An abnormally large immature red blood cell (erythroblast) found especially in the blood of people with certain types of anemia and often associated with vitamin B₁₂ deficiency.

meg′a·lo·blas′tic adj.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

megaloblast

(ˈmɛɡələʊˌblɑːst)

(Medicine) an abnormally large red blood cell precursor, present in certain types of anaemia

megaloblastic adj

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

meg•a•lo•blast

(ˈmɛg ə ləˌblæst)

n.

an abnormally large immature dysfunctional red blood cell found in the blood esp. of persons with pernicious anemia.

[1895–1900]

meg`a•lo•blas′tic, adj.

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Noun

megaloblast - abnormally large red blood cell present in pernicious anemia and folic acid deficiency

erythrocyte, RBC, red blood cell - a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues; a biconcave disc that has no nucleus

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References in periodicals archive ?

Photomicrograph of Megaloblastic Anaemia; aspirate shows Megaloblasts with Sieve-Like Chromatin and Giant Metamyelocyte (Leishman Stain 1000x).

BONE MARROW EXAMINATION- A TWO-YEAR STUDY AT A TERTIARY CARE CENTRE

Uchino, "Proliferation of megaloblasts in pernicious anemia as observed from nucleic acid metabolism," Blood, vol.

Acquired Thrombotic Thrombocytopenic Purpura in a Patient with Pernicious Anemia

Megaloblastic anemia is an anemia that is characterized by the presence of precursor cells, megaloblast in the bone marrow and macrocytic red cells in the peripheral blood.4 These megaloblasts arise because of impaired DNA synthesis followed by ineffective erythropoiesis.4

MEGALOBLASTIC ANEMIA AND PATTERN OF ITS PRESENTATION IN CHILDREN

Without the vitamin the red cells can become enlarged and will be immature and a strange shape (megaloblasts) and, as a consequence of this, they will be unable to marry with the oxygen-carrying Haemoglobin to deliver oxygen to wherever it is needed in the body--which is, incidentally, everywhere.

Pernicious Anaemia, Vitamin B12 deficiency and the podiatrist

This leads to megaloblastic anaemia, in which large, abnormal red cells (megaloblasts) form in the bone marrow and production of normal red blood cells is curtailed.