CMP-001 is designed to activate innate immunity to convert "
uninflamed" tumors, which generally do not respond to anti-PD-1/L1 therapy, into "inflamed" tumors, which are responsive to PD-1 inhibition.
Fluoroquinolones are the most commonly used first-line oral antimicrobials for the treatment of CBP due to their superior penetration into
uninflamed prostatic fluids or secretions (10-50% of serum concentrations) [2, 14, 15].
Histologically, the analyzed biopsy contained newly formed bone, residual grafting material, and vascularized
uninflamed connective tissue.
Fellow eyes also had abnormalities of the tear film function, and nearly 50% of these eyes had
uninflamed pinguecula (40%) or pterygium (9%).
In the case of the control group, samples were taken from random colon sections; samples from colitis-induced animals were taken from inflamed colon region as well as from nonadjacent
uninflamed region.
Histological examination of tissues had revealed characteristic finger-like projections of tissue lined by an increased number of squamous cells and by the
uninflamed fibrovascular core containing small blood vessels with conserved cellular orientation and normal differentiation without signs of cytological atypia (Figure 2).
(35) However, CCR10 is largely absent from the T cells in
uninflamed skin; (33,36) hence, the CCL17/CCR10 axis appears to be important for T cell migration into inflamed skin but not for the constitutive T cell migration into normal skin.
Even though skin and oral mucosae are continuously in contact with commensal and opportunistic microorganisms, they generally remain healthy and
uninflamed. Host defense peptides (HDPs) make up the body's first line of defense against many invading pathogens, including bacteria, fungi, and viruses.