Kabasakal, Synthesis of some novel heterocyclic compounds derived from
diflunisal hydrazide as potential anti-infective and anti-inflammatory agents, Eur.
Celecoxib, diclofenac,
diflunisal, etodolac, fenoprofen,
TTR stabilizers like tafamidis (approved in the European Union and Japan for ATTR-mt) and
diflunisal are being investigated on multiple clinical trials [5].
(g) lbuprofen, aceclofenac, acemetacin, dexibuprofen, dexketoprofen, diclofenac sodium,
diflunisal, etodolac, fenbufen, fenoprofen, flurbiprofen, ibuprofen, indometacin, ketoprofen, mefenamic acid, meloxicam, nabumetone, naproxen, piroxicam, sulindac, tenoxicam, tiaprofenic acid, diclofenac/misoprostol.
Cardoso et al., "Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated
diflunisal derivative," Biochemical Journal, vol.
The researchers discovered that salicylic acid, a major compound in aspirin, and
diflunisal, an analgesic that's derived from salicylic acid, suppress two key proteins, p300 and CREB-binding protein.
In recent years, many new therapeutic strategies have been proposed and several ongoing therapeutic trials involving, for instance, stabilizers of transthyretin tetramers (tafamidis and
diflunisal) and gene therapies to suppress transthyretin expression.
NSAID classification Non-selective inhibition Acetic acid Proprionic acid Fenamate derivatives derivatives derivatives * Diclofenac * Fenoprofen * Meclofenamate * Etodolac * Flurbiprofen * Mefenamic acid * Indomethacin * Ibuprofen * Sulindac * Ketoprofen * Tolmetin * Naproxen * Oxaprozin Naphthyl alkanone Salicylates * Nabumetone * Aspirin *
Diflunisal * Choline magnesium trisalicylate * Salicylate Enolic acid derivatives * Piroxicam * Meloxicam Selective COX-2 inhibition * Celecoxib * Rofecoxib Table 9.
Swinson, "Naproxen sodium,
diflunisal, and placebo in the treatment of chronic back pain," Annals of the Rheumatic Diseases, vol.
Stables, "Synthesis and biological activities of
diflunisal hydrazide-hydrazones," European Journal of Medicinal Chemistry, vol.