bacteriolysis

In April 2019, the Company announced the publication of an article titled 'The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood to Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis' in the April edition of the peer-reviewed Antimicrobial Agents and Chemotherapy Journal of the American Society of Microbiology.

ContraFect announced that its manuscript titled "The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis" was published in the April edition of the peer-reviewed Antimicrobial Agents and Chemotherapy Journal of the American Society of Microbiology.

(1994), propolis disorganizes the cytoplasm, the cytoplasmic membrane, and the cell wall, causing partial bacteriolysis, thus inhibiting the protein synthesis of the gram-positive strains.

Phage therapy has various merits over antibiotics: (1) bacteriolysis mechanisms by phages differ from antibiotics mechanisms (21) so, it is very effective against antibiotic-resistant bacteria; (2) bacteriophages are very specific so, they will be harmless to other beneficial bacteria in human guts; (3) Phages undergo mutations so, they can respond quickly to phage-resistant mutants; (4) ease of isolation; (5) no side effects are known so far; (6) high therapeutic index, smaller effective dose, and a single shot is required; (7) production of phages are very quick and cheap as compared to development of a new antibiotic (22, 23).