Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"

anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation

Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract

rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004

Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract

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In general, one would expect the impact of Vioxx or Celebrex brand television DTCA to shorten the time that patients wait before initiating any COX-2 inhibitor treatment--in which case the parameter on the advertising measures will be negative and significant.

The effect of direct to consumer television advertising on the timing of treatment

For this study, we were interested only in those recipients who were continuously taking either a COX-2 inhibitor, an NSAID, or other pain relieves throughout the 2-year study period.

Impact of medicaid prior authorization requirement for COX-2 inhibitor drugs in Nebraska

Although we still have a COX-2 inhibitor option with the availability of celecoxib (Celebrex), there are two major impediments to its use.

The importance of gastroprotection

To test whether thwarting COX-2 would have an effect on mice predisposed to pancreatic cancer, the researchers fed chow containing a COX-2 inhibitor called nimesulide to mice harboring the Kras mutation.

Anti-inflammatory prevents pancreatic cancer in mice

26 in the journal Circulation, the American Heart Association (AHA) cautions doctors about recommending the COX-2 inhibitor celecoxib (Celebrex), and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit this enzyme.

Experts recommend cautious use of NSAIDS

The journal Clinical Cancer Research has published research indicating that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of prostate cancer.

Green Tea could slow prostate cancer

The Food and Drug Administration has issued a nonapprovable letter for the COX-2 inhibitor etoricoxib (Arcoxia), according to the drug's manufacturer, Merck & Co.

New COX-2 inhibitor drug called nonapprovable by FDA

Green tea alone reduced tumor growth by 42%, and the Cox-2 inhibitor celecoxib slowed it by 57% on its own, according to a study published in last week's issue of the journal Clinical Cancer Research.

A combination of green tea and the pain-relieving ingredient in Pfizer Inc.'s

Jurors in these cases have a conceptual causation hurdle to overcome because no specific "signature injury" is associated with Cox-2 inhibitor use.

Embracing risk factors in pharmaceutical litigation: plaintiff lawyers tend to be reluctant to take on a drug injury case unless the client has few or no risk factors for the injury alleged. But attorneys who take the road less traveled may discover it's the quickest path to success

Vioxx, a COX-2 inhibitor in anti-inflammatories, was banned in 2004 after it was shown that patients on the drug were more than twice as likely to have heart attacks as those not taking it.

Painkiller clue to seizures

Research has found that the Cox-2 inhibitor celecoxib, which is used to treat arthritis and acute pain, increases by more than twofold the risk of a heart attack.

Scientist urges rethink after secondarthritis drug found to be linked to heart attacks

withdrew its popular COX-2 inhibitor Vioxx from the global market last September after a study showed that it doubled patients' risk of heart attacks and strokes.