yeast artificial chromosome


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Related to yeast artificial chromosome: Bacterial artificial chromosome

yeast artificial chromosome

n. Abbr. YAC
A large sequence of DNA that is artificially inserted into a yeast genome for replication or expression.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Abbreviations: BAC, bacterial artificial chromosome; EST, expressed sequence tagged site; kb, kilobase; kbp, kilobase pairs; Mb, megabase; STC, sequence tagged connector; YAC, yeast artificial chromosome.
(In 1996 Resnick, with NIEHS colleagues Vladimir Larionov and Natalya Kouprina, perfected a method using yeast artificial chromosomes, or YACs, for the specific isolation of entire human genes.) In another, changes are introduced into homologous genes or cloned genes in model systems.
A DNA contig of this region spanning 2,400 kb was constructed from large-capacity yeast artificial chromosomes and P1 bacteriophage clones (76).