If we have enough of these markers then we can track the movement of fairly small sections of DNA as they
reassort through recombination and sexual reproduction to create individual genomes.
Le systeme n'a pas marche, car quand vous prenez une franchise chez eux, vous devez gerer directement les 300 enseignes (negociation,
reassort, logistique ...).
Stated succinctly, native intermediates of E1 cannot exist in solution because cysteines will
reassort as the high energy form becomes stable.
[11] found that the H6N1/N2 subtype viruses identified in the same region from 2000 to 2005 were derived from W312-like virus, and their genomes may
reassort continually with those of H5N1 and H9N2 viruses.
Officials from the Centers for Disease Control and Prevention said in a statement that there is no evidence of human-to-human transmission of the virus but the concern is that the virus could "change and adapt to allow efficient transmission during the infection of mammals or
reassort its gene segments with human influenza viruses during the co-infection of a single host, resulting in a new virus that would be transmissible from person to person."
The inherent ability of the RNA viruses to recombine and
reassort can lead to genetic mutations and change in host range.
These risk factors include: the prevalence of the virus in livestock; its ability to bind to receptors in the human airway; its ability to grow in human cells/organs; its airborne transmissibility between ferrets (the best animal models for studying human transmission because they can transmit influenza viruses and develop clinical signs similar to those seen in humans including fever, rhinitis, and sneezing); and its ability to
reassort with human influenza viruses.
If one is unlucky enough to be simultaneously infected with an avian influenza virus and a human influenza virus, the genes in each of these two viruses can randomly
reassort, or rearrange themselves, to form a new virus.
"When respiratory viruses get into these confinement facilities, they have continual opportunity to replicate, mutate,
reassort, and recombine into novel strains," Gray explains.
The concern, of course, is that the seasonal H1N1 strain of last winter will
reassort with the newly circulating novel influenza H1N1 strain to produce a new strain treatable only with Relenza.
Questions still remain about whether the disease can change or
reassort, particularly should outbreaks in countries simultaneously contending with H5N1 bird flu cases occur (such as Egypt, Vietnam, and Indonesia).
The more times this virus can get into a human, the more opportunities it will have to
reassort, mutate, or both into a form that could trigger the pandemic that many fear.