fibrinolysis

Hsieh Po-chuan, a professor at Tajen University's Department of Pharmacy who participated in the study told ETtoday that many enzymes or proteins extracted from pineapples in the past have provided pharmaceutical properties such as to countering inflammation, edema, thrombosis, and fibrinolysis. These extracts from pineapples have been used to treat acute inflammation, exercise injuries, cardiovascular abnormalities, menstrual abnormalities, pulmonary edema, obesity, and prevent colorectal cancer.

Fortunately, fibrinolysis, catheter intervention, and possible col-laboration with cardiac surgeons for desperately sick patients are tools that will assist cardiovascular specialists in maximizing the likelihood of prompt and complete recovery in these seriously ill patients.

Recanalization is a complex method that involves thrombus regresses, fibrinolysis and neovascularization.

A primary PC strategy is recommended over fibrinolysis within indicated time frames.

Atherosclerosis underlying cardiovascular mortality is the leading cause of death in developed countries.3 D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrin protein.

UFH, which can be rapidly reversed, is preferred in patients undergoing fibrinolysis or embolectomy.

Recent studies have shown that thrombin activatable fibrinolysis inhibitor (TAFI), in addition to suppressing fibrinolysis, can be involved in the inflammatory process as a natural anti-inflammatory molecule.

"Mechanistic work suggests that atopic eczema may be associated with increased platelet activation and decreased fibrinolysis, which may increase the risk of clotting, though a recent study found no association with metabolite levels," the authors wrote.

Although technical errors in haemostasis account for the majority of cases, but fibrinolysis, coagulopathy originating from heart-lung machine, churning of platelets in perfusion circuit and its dilution effect may cause platelet dysfunction and critical thrombocytopenia leading to a drop in platelet count and an excessive non-surgical blood loss1.

[1] It results from a multifactorial coagulopathy in which the predominant factors are thrombocytopenia, acquired platelet dysfunction, loss of clotting factors, unneutralised heparin and increased fibrinolysis. The incidence of re-exploration as reported worldwide is about 2%-6%.