(66) stated that the substitution of urea/thiourea on
disubstituted cinnamic-based hydroxamates (10) has a remarkable HDAC inhibitory effect and antiproliferative activity against tumor cell lines.
Also, being
disubstituted affords the ability to vary functional groups, offering greater control of polymer properties, according to the company.
The main sign of polymerization of monomers is the dramatic decrease of characteristic bands around 930-940 [cm.sup.-1], attributed to the out-of-plane deformation mode of the [alpha],[beta]-
disubstituted naphthalene ring, which indicates the opening of the oxazinic ring.
Hence, [WA-f.sub.50] and [WB-f.sub.75] had significantly different inhibition potency towards [alpha]-glucosidase activity despite having similar relative proportions unsubstituted (un-Xylp), monosubstituted, (2-Xylp or 3-Xylp), and
disubstituted xylose residues (2,3-Xylp) and degree of substitution but different ferulic acid content.
report the preparation of
disubstituted metal cholate hydrogel without any proper identification of products [17].
Some authors also have reported that the kinetic diffusion of the less-stable
disubstituted anthocyanins is faster than that of the trisubstituted ones.
99% of which is 2-6
disubstituted piperidines, which have haemolytic, antibacterial, insecticidal and cytotoxic properties.
A recent comparative study of the antioxidant activity of several coumarins showed that 4-methylumbelliferone was completely inactive against liver toxicity induced by carbontetrachloride, whereas other C-6 and C-7
disubstituted coumarins (esculetin and scoparone) significantly prevented oxidative stress induced by carbon-tetrachloride (Bilgin et al., 2011).
Recently, Prashanth and Revanasiddappa showed antimicrobial activity of glutamine linked 2, 3
disubstituted quinazolinone derivatives as potent antimicrobial agent against both gram positive and gram negative bacteria [10].
Quadrelli, "HNO made-easy from photochemical cycloreversion of novel 3,5-heterocyclic
disubstituted 1,2,4-oxadiazole-4-oxides," Tetrahedron, vol.
Use of Grignard reagents allows for the isolation of monosubstituted and
disubstituted products, whereas use of organolithium reagents allows for the isolation of only the
disubstituted product.
The disappearance of the band at 1489 [cm.sup.-1] (
disubstituted benzene ring) (53) and the decrease of the peak at 753 [cm.sup.-1] (
disubstituted benzene ring) (53) were also noted.