MEET THE STATINS EXAMPLES DOSAGE LDL (in milligrams) REDUCED High-Intensity Atorvastatin 40-80 mg (Lipitor[R]) 50% or Rosuvastatin 20-40 mg more (Crestor[R]) Moderate-Intensity Atorvastatin 10-20 mg Rosuvastatin 5-10 mg Simvastatin 20-40 mg (Zocor[R]) Pravastatin 40-80 mg (Pravachol[R]) Lovastatin 40-80 mg 30%-49% (Altoprev[R], Mevacor[R]) Pitavastatin 1-4 mg (Levalo[R]) Fluvastatin 40 mg (Lescol[R]) (twice daily) Fluvastatin XL 80 mg (
Lescol XL[R]) Low-Intensity Simvastatin 10 mg Pravastatin 10-20 mg Less Lovastatin 20 mg than 30% Fluvastatin 20-40 mg Source: 2018 ACC/AHA Guideline on the Management of Blood Cholesterol, Circulation, Nov.
Common statins are Lipitor,
Lescol, Lipostat, Zocor and Crestor.
The hydrophilic statins--pravastatin (Pravacol), rosuvastatin (Crestor) and fluvastatin (
Lescol)--are less likely to affect the muscles than the other four statins.
There are seven HMG-CoA inhibitors, known as statins: atorvastatin (Lipitor), fluvastatin (
Lescol), lovastatin (Mevacor), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor).
M2 EQUITYBITES-September 21, 2015-Mylan unveils first generic
Lescol XL cholesterol tablets in the US market
M2 PHARMA-September 21, 2015-Mylan unveils first generic
Lescol XL cholesterol tablets in the US market
We have not counted the ADRs associated with the use of pravastatin (Pravachol), lovastatin (Mevacor), simvastatin (Zocor), and fluvastatin (
Lescol) in either their single or combined use.
FRS: Framingham risk score; RTR: renal transplant recipients; IHD: ischemic heart disease; MI: myocardial infarction; CHF: congestive heart failure; SCr: serum creatinine; CV: cardiovascular; CVD: cardiovascular disease; MACE: major adverse cardiovascular event; CHF: congestive heart failure; PVD: peripheral vascular disease; DGF: delayed graft function; AR: acute rejection; eGFR: estimated glomerular filtration rate; CRP: C-reactive protein; UA: uric acid; urine ACR: urine albumin-to-creatinine ratio; MVA: multivariate analysis; ALERT: Assessment of
Lescol in Renal Transplantation; CSA: cyclosporine; IS: immunosuppression; CHD: coronary heart disease; PORT: patient outcomes in renal transplant; LDL: low density lipoprotein cholesterol.
Pfizer's blockbuster cholesterol treatment, Lipitor, has become the world's best-selling drug, and by 2009, cholesterol-lowering medications, including Crestor, Questran and
Lescol, were generating sales of more than $25 billion.
Six statin drugs are available in the United States: atorvastatin (Lipitor), fluvastatin (
Lescol), lovastatin (Mevacor, Altoprev), pravastatin (Pravachol), simvastatin (Zocor) and rosuvastatin (Crestor).
* There are different levels and potencies of statins, with atorvastatin (Lipitor) and rosuvastatin (Crestor) the most potent and fluvastatin (
Lescol) the least potent.Treatment goal is to lower cholesterol levels by 25 to 30 percent.
Such a move holds the promise of giving consumers access to chronic-condition drugs such as Avapro, Diovan and Atacand for hypertension;
Lescol and Tricor for hyperlipidemia; Maxalt and Zomig for migraine; and Singulair and Xopenex for asthma.