Given its potential nephrotoxicity and potential preexisting renal compromise in this patient population, lower doses (0.25-1mg/kg/ once/week versus traditional 3-5mg/kg/week), administration through an intravesical route via urethral catheter (invasive), or combination with
probenecid, have all been proposed to reduce potential renal injury.
If you can't tolerate either of the XOIs, your physician may prescribe the uricosuric drug
probenecid, which lowers uric acid by increasing its excretion by the kidneys.
In a retrospective study in which the treatment methods of gout were evaluated, a NSAII was used at the rate of 41.7%, colchicine 16.7%, corticosteroid 21%,
probenecid 1.4%, and allopurinol 31.8%, and 39% of the patients reported that they did not receive any treatment (5).
The World Anti-Doping Agency list also includes
probenecid, 5[alpha] reductase inhibitors, diuretics and ketoconazole [19].
In the second trial, known as sulopenem for resistant enterobacteriaceae, or SURE 2, IV sulopenem followed by oral sulopenem etzadroxil combined with
probenecid in a bilayer tablet will be compared to IV ertapenem followed by oral ciprofloxacin in adults with complicated urinary tract infections.
Available US Food and Drug Administration (FDA)-approved options for lowering sUA include xanthine oxidase inhibitors (allopurinol and febuxostat) that prevent production of uric acid; a uricosuric agent (
probenecid) that increases uric acid output in urine; and a uric acid-specific enzyme (pegloticase) that converts uric acid to allantoin.
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by
probenecid. Int J Cancer 2005;116:824-829.
Medication causing decreased renal elimination (aminoglycosides, cyclosporine, nonsteroidal anti-inflammatory agents, sulfonamides,
probenecid, salicylates, penicillin, colchicine, cisplatin, and other nephrotoxic drugs) and drugs causing displacement of methotrexate from its protein-binding sites (salicylates,
probenecid, sulfonamides, barbiturates, phenytoin, retinoids, sulfonylureas, and tetracyclines) significantly increase its toxicity.
Barbhaiya, "Pharmacokinetic Interactions of Cefprozil With Food, Propantheline, Metoclopramide, and
Probenecid in Healthy Volunteers," The Journal of Clinical Pharmacology, vol.
Probenecid, a Panx1 inhibitor, protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity [44].
IV amikacin and cefoxitin with
probenecid were started, and intravenous ampicillin/sulbactam was discontinued.
Homovanillic acid and 5-hydroxyindoleacetic acid cerebrospinal fluid levels: a study with and without
probenecid administration of their relationship to the state of consciousness after head injury.