osteoclast


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os·te·o·clast

 (ŏs′tē-ə-klăst′)
n.
1. A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.
2. An instrument used in surgical osteoclasis.
[osteo- + Medieval Latin -clastēs, breaker (from Late Greek -klastēs, from Greek klastos, broken, from klān, to break).]
os′te·o·clas′tic adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

osteoclast

(ˈɒstɪəʊˌklæst)
n
1. (Surgery) a surgical instrument for fracturing bone
2. (Physiology) a large multinuclear cell formed in bone marrow that is associated with the normal absorption of bone
ˌosteoˈclastic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

os•te•o•clast

(ˈɒs ti əˌklæst)

n.
1. a skeletal cell that functions in bone formation.
2. a surgical instrument for effecting osteoclasis.
[1870–75; osteo- + -clast < Greek klastós broken]
os`te•o•clas′tic, adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.osteoclast - cell that functions in the breakdown and resorption of bone tissue
bone cell - a cell that is part of a bone
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations
Osteoklast
luunsyöjäsolu

os·te·o·clast

n. osteoclasto, célula gigante multinucleada que participa en la formación de tejido óseo y reemplaza al cartílago durante la osificación.
English-Spanish Medical Dictionary © Farlex 2012
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References in periodicals archive ?
Corticosteroids, such as prednisolone, can negatively impact bone health by increasing osteoclast apoptosis, reducing ossification and leading to increased bone resorption and osteoporosis.
Catabasis Pharmaceuticals presents preclinical data on edasalonexent in DMD
At some point, the epithelium of the main pancreatic duct clearly displayed cytological atypia and became stratified with a sudden shift to pleomorphic mononuclear round and spindle cells chaperoned by benign looking osteoclast giant cells.
Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review
Over-expression of CD147 can effectively promote osteoclast formation
Up-regulated expression of CD147 gene in malignant bone tumor and the possible induction mechanism during osteoclast formation
CCL3 also functions as a chemotactic molecule for mature osteoclasts (13) and osteoclast precursor cells (14).
Correlation of Serum CCL3/MIP-1a Levels with Disease Severity in Postmenopausal Osteoporotic Females
Brown et al., "Osteoclast formation from circulating precursors in osteoporosis," Scandinavian Journal of Rheumatology, vol.
"Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition
* Suitable ratio for co-culturing peripheral blood mononuclear cells with differentiated osteoblasts was 1 osteoclast: 2 osteoblasts.
Optimization of the Static Human Osteoblast/Osteoclast Co-culture System
Peles et al., "Bortezomib inhibits osteoclast activity in patients with multiple myeloma," Clinical Lymphoma & Myeloma, vol.
Deubiquitinating Enzymes and Bone Remodeling
* Most anti-osteoporosis drugs act mainly by stopping osteoclast activity, with little impact on bone-forming osteoblasts.
PQQ Prevents Bone Loss in Male Mice. (REPORT)
In bone tissue, PTH increases osteoclast formation and bone resorption by regulating the receptor activator of nuclear factor kappa B ligant (RANKL)/osteoprotegerin (OPG) expressed in osteoblasts.
Modulation of in vitro Osteoclast Activity Mediated by Different Doses of Parathyroid Hormone/Modulacion in Vitro de la Actividad Osteoclastica Mediada por Diferentes Dosis de Hormona Paratiroidea
miRNA mimics thus can be used for rebalancing inflammatory and bone cell phenotypes in conditions such as RA [9], promoting osteoblast differentiation, and inhibiting osteoclast activity.
Combination of Interleukin-27 and MicroRNA for Enhancing Expression of Anti-Inflammatory and Proosteogenic Genes

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