Crotoxin (CTX) is the main toxin isolated from Brazilian rattlesnake Crotalus durissus terrificus (C.
(6) Cobra venom contains cobratoxin and a-bungarotoxin which act postsynaptically by binding to acetylcholine receptors on the motor end plate while (3-bungarotoxin and
crotoxin present in krait venom act pre-synaptically and prevent release of acetylcholine at the neuromuscular junction resulting in muscle paralysis due to curare like neuromuscular blocking action affecting the muscles of eyes, throat and chest leading to respiratory failure.
alba and three of its constituents, wedelolactone, sitosterol, and stigmasterol, have been investigated for their ability to protect against myotoxicity of crotalid venoms (Bothrops jararaca, Bothrops jararacussu, and Lachesis muta) and purified myotoxins (bothropstoxin, BthTX; bothropasin; and
crotoxin) through quantification in vitro by the release rate of creatine kinase (CK) from rat or mouse extensor digitorum muscles and in vivo by the plasma CK activity in mice.
Whole Crotalus durissus terrificus snake venom induces antinociception in a rat model of cancer pain and
crotoxin inhibits tumor growth.
Domont et al., "Molecular structure and mechanism of action of the
crotoxin inhibitor from Crotalus durissus terrificus serum," European Journal of Biochemistry, vol.
Investigations on the mechanism of action of
crotoxin. J.
Crocalbin: a new calcium-binding protein that is also a binding protein for
crotoxin, a neurotoxic phospholipase [A.sub.2].
Edema happens due to direct poison action in muscles, and it has systemic effects on
crotoxin, phospholipase A2, and several other substances that are released in the acute inflammatory phase such as interleukin, bradikinine and histamine (Kini & Evans 1989, Barraviera 1994).
Presynaptic effects of snake venom toxins which have phospholipase A2 activity (beta-bungarotoxin, taipoxin,
crotoxin).
Crotoxin, the phospholipase A2 neurotoxin from the venom of Crotalus durissus terrificus.