MIC endpoints were determined for nine antifungal agents: micafungin, caspofungin, flucytosine, posaconazole, voriconazole, itraconazole, fluconazole, anidulafungin and
amphotericin B.
The tablets were found to release the drug
Amphotericin B in a sustained and controlled manner over a period of 10 days, read a statement from the institution.
Food and Drug Administration has designated MAT2203, Matinas' proprietary oral
amphotericin B product, as a Qualified Infectious Disease Product with Fast Track status for the treatment of cryptococcal meningitis.
A life-saving drug for people living with HIV is missing in most high traffic HIV clinics in the country, the Nation has learnt.The drug, liposomal
amphotericin B (L-AMB), is highly effective when used in combination with other medicines to treat cryptococcal meningitis, the second biggest killer of people living with HIV after tuberculosis.
Amphotericin B concentrations in healthy mallard ducks (Anas platyrhynchos) following a single intratracheal dose of liposomal
amphotericin B using an atomizer.
Two of the 9 patients required liposomal
amphotericin B after failing to respond to micafungin therapy.
Following its discovery in 1953,
amphotericin B (amB) has remained the treatment of choice for most systemic fungal infections affecting immunocompromised patients (Pagano et al., 2010).
A diagnosis of infection-related hemophagocytic lymphohystiocytosis (HLH) was made and intravenous immunoglobulin (1 g/kg/day) was administered for two days and intravenous liposomal
amphotericin B (3 mg/kg/day) was given in association.
Intrathecal
amphotericin B treatment was considered due to the arrest in his condition with no significant improvement.
Unlike bacterial and viral meningitis, adjunctive corticosteroid therapy is contraindicated for the management of CM and treatment is always long-term consisting of three phases: 2 weeks of induction therapy with
amphotericin B plus flucytosine, and a further 8-10 weeks of consolidation with fluconazole 400-800mg daily followed by long-term fluconazole (200mg daily) therapy for maintenance phase, also known as secondary prophylaxis for at least 1 year [46].
These include the polyene group that encompasses
amphotericin B deoxycholate and its lipid formulations (liposomal
amphotericin B,
amphotericin B lipid complex, and
amphotericin B cholesteryl sulfate complex); the nucleoside analogue flucytosine; the triazoles which include fluconazole and voriconazole; and the most recently developed echinocandin class, which includes caspofungin, micafungin, and anidulafungin.