However, even though significant clusters represent a spatially unconstrained information about "how"
BOLD fMRI activity is different across groups or in relation to a given variable (e.g., age), they do not specify whether, for instance, the connectivity profile of cluster A (e.g., located in the right temporal lobe) is different in patients and controls because of its decreased connectivity with a specific other region of the brain, or multiple others, or an entire hemisphere, and so on.
Kable, "The valuation system: A coordinate-based meta-analysis of
BOLD fMRI experiments examining neural correlates of subjective value," NeuroImage, vol.
Clinical
BOLD fMRI and DTI: Artifacts, Tips, and Tricks.
And the scanner's submillimeter
BOLD fMRI contrast increases linearly with field strength; this could translate, in clinical use, to higher resolution in neuro imaging compared to 3T applications.
Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and
BOLD fMRI. Neuroimage 2009; 48: 166-175, doi: 10.1016/j.neuroimage.2009.05.026.
Diffusion MRI and its use in diagnosing strokes,
BOLD fMRI, and the various ways in which the behavior of water in the brain impacts imaging methods are elaborated.
(199.) See Adelsheim, supra note 97, at 888-95, 908 (discussing
BOLD fMRI and its inherent weaknesses); Brown & Murphy, supra note 48, at 1138-41,1188 (discussing the various layers along the chain of inferences that must be made in order to create an fMRI image and deduce conclusions from it).
In
BOLD fMRI (see later explanation), the most common form of fMRI, a relatively long TE will yield greater changes in functional signal between activation and baseline states, but will also cause greater artifacts near air-tissue interfaces and lessened overall signal intensity.